https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16551 Wed 11 Apr 2018 17:05:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16517 Wed 11 Apr 2018 16:11:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38421 Wed 08 Sep 2021 16:45:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40215 Wed 06 Jul 2022 16:26:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24307 A receptor subunits that normally heighten neurosteroid sensitivity. These stressors also result in altered placental allopregnanolone metabolism pathways. These findings suggest that reduced neurosteroid production and action in the perinatal period may contribute to some of the adverse neurodevelopmental and behavioural outcomes that result from these pregnancy compromises. Studies examining perinatal steroid supplementation therapy with non-metabolisable neurosteroid analogues to improve these outcomes are warranted.]]> Thu 21 Oct 2021 12:51:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16534 Thu 21 Jul 2022 15:38:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13396 Sat 24 Mar 2018 10:35:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8167 440 msec) was assessed by kappa coefficients. Results: QT interval intraobserver ICC was 0.86 and repeatability coefficient was 25.9 msec; interobserver ICC increased from 0.88 for single observations to 0.94 for the average of 3 measurements and repeatability coefficients decreased from 22.5 to 16.7 msec. For QTcB, intraobserver ICC was 0.67, and repeatability was 39.6 msec. Best interobserver reliability for QTcB was for the average of three measurements (ICC 0.83, reproducibility coefficient 25.8 msec), with further improvement for QTcH (ICC 0.92, reproducibility coefficient 16.69 msec). Maximum interobserver kappa for prolonged QTc was 0.77. Misclassification around specific cut points occurs because of the repeatability coefficients. Conclusions: Uncorrected QT measures are more reliable than QTcB and QTCFrid. An average of three independent measures provides the most reliable QT and QTc measurements, with QTcH better than QTcB.]]> Sat 24 Mar 2018 08:36:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1173 Sat 24 Mar 2018 08:28:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14780 Sat 24 Mar 2018 08:26:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13872 Sat 24 Mar 2018 08:25:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12443 Sat 24 Mar 2018 08:17:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16519 Sat 24 Mar 2018 08:01:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20697 100/mm³. Conclusion Early diagnosis of enteroviral meningoencephalitis could alter management, potentially reducing the period of treatment with empirical antimicrobials and permitting earlier discharge.]]> Sat 24 Mar 2018 07:55:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5597 Sat 24 Mar 2018 07:49:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5474 Sat 24 Mar 2018 07:47:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5013 Sat 24 Mar 2018 07:44:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28160 Sat 24 Mar 2018 07:36:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26513 0.05) but low PCN decreased the size of the neonate (crown-rump-length and metacarpal length P< 0.05). A subset of lambs euthanased at 5 days of age further showed that low PCN decreased the amount of peri-renal fat (P < 0.05) and increased liver mass (P < 0.05) while high PCN increased neck thymus and ovary mass (P < 0.05). Neonatal lambs from low PCN ewes returned faster to their mothers after release (P < 0.05) and contacted the udder in the shortest time (P < 0.05). Significant interactions between PCN treatment and sex (P < 0.05) and between PCN treatment and ewe age (P < 0.05) were also observed for time lambs took to follow the ewe. Survival of lambs was similar but potential differences may have been masked by favourable weather conditions. In conclusion, this study provides evidence of significant changes in lamb growth and development dependent on PCN and, for the first time, links these changes with significant changes in behaviour of the neonate. The impact of these effects on lamb survival and potential reproductive capacity of female offspring remains to be determined.]]> Sat 24 Mar 2018 07:35:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30838 Sat 24 Mar 2018 07:33:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29502 Sat 24 Mar 2018 07:29:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26443 Sat 24 Mar 2018 07:27:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4813 Sat 24 Mar 2018 07:20:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22253 Sat 24 Mar 2018 07:17:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22112 Chlamydia muridarum bacteria on glucocorticoid (GR) and mineralocorticoid (MR) receptors in the adult mouse hippocampus. In male adults infected at birth, circulating corticosterone was significantly increased when compared to same sex controls; while neonatal infection resulted in female adults with significantly increased GR mRNA compared to same sex controls. When comparing males and females after neonatal infection, males had significantly less GR protein than females. Interestingly, after control treatment, males had significantly more GR mRNA, MR mRNA, and GR protein with significantly lower corticosterone than females. Neonatal respiratory infection significantly impacts adult hippocampal GR and MR, and circulating corticosterone in a sex-specific manner potentially altering stress responsivity.]]> Sat 24 Mar 2018 07:13:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46877 Mon 05 Dec 2022 09:47:37 AEDT ]]>